Drug interactions EPCLUSA is a prescription medicine used to treat adults with chronic hepatitis C (Hep C) genotype 1-6 infection with or without cirrhosis (compensated).. H2-receptor antagonists • Administer simultaneously with or 12 hours apart from … Drugs affecting sofosbuvir/velpatasvir. When is Epclusa contraindicated? 7 DRUG INTERACTIONS 7.1 Potential for Other Drugs to Affect EPCLUSA 7.2 Potential for EPCLUSA to Affect Other Drugs 7.3 Established and Potentially Significant Drug Interactions 7.4 Drugs without Clinically Significant Interactions with EPCLUSA 8 USE IN SPECIFIC POPULATIONS 8.1 Pregnancy 8.2 Lactation It is possible that side effects, such as a reduced number of red blood cells, may develop if these drugs are given together. Important Safety Information. Epclusa is a new drug and not everything is known about its effect on people. Drug-drug interactions can decrease how well your medications work, may increase minor or serious unexpected side effects, or even increase the blood level and possible toxicity of a certain drug. SMC No. Sofosbuvir and velpatasvir work by blocking … Side effects. Both of these medications belong to the class of medications called antivirals. Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP while GS-331007 is not. What is clear from the drug interaction studies with Epclusa is that the anti-HIV drug efavirenz (Sustiva, Stocrin and in Atripla) must not be used because it can reduce absorption of velpatasvir by about 50%. Table 4: Interactions between Epclusa and other medicinal products. The most common side effects of Epclusa are: fatigue; headache; In most cases these side effects are mild or moderate. Hormonal contraceptives (“the pill”) No loss of efficacy with oral contraceptives containing norgestimate/thinly … Sofosbuvir with velpatasvir (Epclusa ®) for the treatment of chronic hepatitis C virus (HCV) infection in adults [with genotype 2, 5 or 6 chronic HCV infection, or decompensated cirrhosis, irrespective of chronic HCV genotype] (October 2017) Recommended with restrictions. Sofosbuvir/Velpatasvir = Epclusa® Ledipasvir/Sofosbuvir = Harvoni® • Acid-reducing medications can decrease the effectiveness of Harvoni® and Epclusa® and could prevent successful cure. Based on drug interaction studies conducted with Epclusa, no clinically significant drug interactions have been observed with atazanavir/ritonavir. Coadministration of EPCLUSA is not recommended with topotecan due to increased concentrations of topotecan. 6.Epclusa (sofosbuvir and velpatasvir) US prescribing information. Epclusa: Sofosbuvir - velpatasvir is used alone or with ribavirin to treat chronic (long-term) hepatitis C virus (HCV) infection. Refer to the amiodarone Product Monograph (see WARNINGS AND PRECAUTIONS, Drug Interactions). What is the most important information I should know about EPCLUSA? Epclusa is the first combination HCV product indicated for the treatment of all genotypes of Hepatitis C with or without cirrhosis. Drug interactions may change how your medications work or increase your risk for serious side effects. Interactions with Harvoni ® and Epclusa ® November 2016 | www.hepatitis.va.gov. The following chart provides information regarding potentially significant drug interactions with Epclusa (the table is not all-inclusive). This section outlines the advice given to doctors and pharmacists when prescribing and dispensing Epclusa Epclusa and ribavirin combination regimen is contraindicated in those patients for whom ribavirin is contraindicated. Drug Interactions. ... Epclusa 400 mg-100 mg tablet. A PK fact sheet for simeprevir replaces the earlier investigational drug fact sheet and is listed with the other fact sheets in the Pharmacology Resources section of this website. Added: Wednesday 21 May 2014 Skip to main content. This combination product contains 2 medications: sofosbuvir and velpatasvir. Coadministration of EPCLUSA is not recommended with topotecan due to increased concentrations of topotecan. For example, famotidine , and proton pump inhibitors ( PPIs ) because they may decrease the effectiveness of Epclusa treatment by decreasing blood … About Us. 1271/17 Build effective decision support tools with the industry’s most comprehensive drug-drug interaction … Drug interaction overview. EPCLUSA … Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP while GS-331007 (the predominant circulating metabolite of sofosbuvir) is not; In vitro, slow metabolic turnover of velpatasvir by CYP2B6, CYP2C8, and CYP3A4 was observed WebMD provides information about interactions between Epclusa Oral and p-glycoprotein-p-gp-inhibitors-relugolix. If you are allergic to Epclusa (sofosbuvir and velpatasvir); any part of Epclusa (sofosbuvir and velpatasvir); or any other drugs, foods, or substances. HEP Drug Interactions. Make sure your doctor knows about all of your medical conditions when you are discussing Epclusa as a treatment option. Table 4 Potentially Significant Drug Interactions: Alteration in Dose or Regimen May Be Recommended Based on Drug … Interactions between simeprevir and comedications can be found on the web, app and printed versions of the charts. Coadministration of EPCLUSA is not recommended with topotecan due to increased concentrations of topotecan. What is the most important information I should know about EPCLUSA? Interaction Checker. ... Epclusa should be administered with food and taken 4 hours before omeprazole 20 mg. Coadministration of omeprazole and sofosbuvir/velpatasvir (400/100 mg single … Drug-drug interactions - These are the most common type of drug interaction. Drug Interactions. Tell your doctor about the allergy and what signs you had. Medicinal product by therapeutic areas/Possible Mechanism of Interaction. If EPCLUSA is administered with amiodarone, close monitoring for bradycardia is recommended. Drug Interactions. Coadministration of atazanavir/ritonavir (300/100 mg once daily with emtricitabine and tenofovir-DF) and sofosbuvir/velpatasvir (400/100 mg once daily) was studied in 24 subjects. Apps. virologic response.These agentsshould not be used with EPCLUSA(see DRUG INTERACTIONS). Interaction Checker. Notes for Consumers: Although an interaction is possible, these drugs can be used together with caution. The drug interactions described are based on studies conducted with either EPCLUSA, the components of EPCLUSA (sofosbuvir and velpatasvir) as individual agents, or are predicted drug interactions that may occur with EPCLUSA. The more medications you take, the greater the chance for your drug interacting with another medicine. Interactions for EPCLUSA (velpatasvir and sofosbuvir tablet, film coated) explain how Epclusa works in concert with other medications and substances. Color: pink Shape: diamond Imprint: GSI 7916. Coadministration of EPCLUSA is not recommended with topotecan due to increased concentrations of topotecan. Cardiovascular Serious Symptomatic Bradycardia When Coadministered with Amiodarone Postmarketing cases of symptomatic bradycardia and cases requiring pacemaker intervention have been reported when amiodarone … WebMD provides information about interactions between Epclusa Oral and bcrp-oatp1b1-and-oatp1b3-substrates-enasidenib. Epclusa : - Store and dispense in original container - Store below 86 degrees F. ... drug-induced hepatic injury, complex drug interactions, overlapping toxicities); therefore, it is recommended to initiate a fully suppressive antiretroviral (ARV) therapy and a hepatitis C regimen in all coinfected patients regardless of CD4 count. If you have ever had liver problems other than hepatitis C. If you are taking another drug that has the same drug … Download from Google Play. Drug interactions of Epclusa include acid reducing agents that are commonly used to treat heartburn, indigestion, and GERD, such as antacids, histamine 2 receptor antagonists. Download from the AppStore. In vitro potential for sofosbuvir/velpatasvir drug-drug interactions. Drug Interactions. Glecaprevir/Pibrentasvir (Mavyret™) Drug Interactions A Quick Guide for Clinicians – February 2019 John J Faragon, PharmD, BCPS, AAHIVP Monitoring of liver function including direct bilirubin is recommended in patients with decompensated cirrhosis (see ADVERSE … Sofosbuvir/Velpatasvir (Epclusa®) Drug Interactions with Common Primary Care Medications Medication and or Class Recommendation and Clinical Comment Antacids • Separate antacids and sofosbuvir/velpatasvir administration by 4 hours. Been observed with atazanavir/ritonavir to increased concentrations of topotecan and p-glycoprotein-p-gp-inhibitors-relugolix with topotecan due to increased of... Regarding potentially significant drug interactions EPCLUSA is the most important information I should about. 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