New comments cannot be posted and votes cannot be cast, More posts from the depressionregimens community, Continue browsing in r/depressionregimens. Press question mark to learn the rest of the keyboard shortcuts, https://www.ncbi.nlm.nih.gov/pubmed/19909689. I'm not saying it doesn't work or that it can't be safe. Rising. A Reddit to share information about who you are, how you think, and what helps you cope in life. If you are not and even worse, if you are overmethylated it will cause more problems instead. This supplement is counterindicated for bipolar. That started to wear off after a few more days so I went up to 1200. SAM-e boosts brain health and function in several ways. This sub is not for venting or for facebook style posts. The people suffering from depression symptoms can take Sam-E for minimum of two weeks to maximum of six weeks depending on the intensity of depression. Now even as tough as she is, she'll reach for a SAM-E every … While research has shown that SAMe has a positive effect in treating depression, most studies weren't well-designed and included a small number of people. If you want any more citations let me know. My doc also approved of it cautiously. Log In Sign Up. But a .74 effect size and a p value better than lexapro (lexapro, right?) You may even be able to completely wean off them! What is this stuff. Sam-E is a natural compound found in our body. Doesn't mean it isn't safe, but you know...why risk it? Source: rawpixel.com. Research on SAMe use for specific conditions shows: 1. Definitely less anxious. We’ve gotta just take it all one day at a … In June of 2017, a group of psychiatrists from four Ivy League Medical Schools and other schools as well, evaluated 132 scientific studies that have been done to determine whether or not SAMe is effective in the treatment of several … It's a supplement, but it's not like your garden variety vitamins and omegas that don't noticeably do anything. But two in particular stand out. What dose did you take? Although these anabolic reactions occur throughout the body, most SAM-e is produced and consumed in the liver. save hide report. I´ve been looking to all the threads about this two supplements. Une carence en ces vitamines peut abaisser le taux naturel de SAM dans l'organisme. You should always start with one pill and increase after one week (if no problem). Sub-Forums: Depression: Search this Forum : Forum: Threads: Posts: Last Post: Postpartum Depression (2 Viewing) 62: 324: I don't have friends and it... by mountainstream. Depression can occur in both men and woman of any age. You’re just as likely to be irrationally angry about something as you are to be sad about it. I´m a little bit concerned about my anxiety and depression. 5 comments. I've been eating turkey every night for the past week while I've been trying to get my sleep under control lol, It's hard to tell how I'm doing at a lower dose because there is definitely, 100% withdrawal with this vitamin. When we feel broken, we lose our self-esteem. New comments cannot be posted and votes cannot be cast, More posts from the BipolarReddit community. Discussion and anecdotes are welcome! … Now like all things in life, it's not perfect - since it's a supplement, it's not covered (in north america) by insurance, and perhaps most relevant for us, it has been shown to induce mania at a rate similar to tricyclics. I know it's the Sam-E because I took it this weekend and everything went away. 1: tricyclics are no longer the gold standard of treating depression and probably shouldn't be the comparison drug class if we're talking about efficacy. Depression. So, paradoxically, it was cheaper for my psychiatrist to try various combinations of prescription medications, all covered by my health insurance, than for … anyone have any experiences with this? I was on two pills as of this Monday, and half a pill as of today. A different study seemingly lends credence to the latter suggestion. I hate having to choose feeling depressed or feeling chronic fatigue. SAM-e helped my situational panic attacks/atypical depression but that was adolescence... Magnesium glycinate absolutely helps anxiety through calcium (or sodium) channel blocking. Press question mark to learn the rest of the keyboard shortcuts . So I started seeing a psychiatrist who formulated her own "mood boosting" vitamin. I don't know if I should give it another month. There have been many scientific studies done of the efficacy of SAMe in the treatment of depression. I'd been taking it for about 6 years and decided to taper down in the past few months. This is just my particular story and I'm just one person, please use caution. … I do much better with SNRIs than I did with SSRIs. A user on Cure Zone said that SAM-E has helped them “almost magically with depression.” This same user said that it is “a … Then it just makes me very very anxious and uncomfortable. Taking it however, made me feel like I was going crazy. 01-30-2021 09:35 PM. I’m a calm person and I’ve never been in a fight in my 30 years of life until I took Sam-e and snapped. I took SAM-e for a couple of months before I was diagnosed with BP. I was depressed at the time. I remember reading somewhere but not where that atypical depression is a more common manifestation in BP than MDD) and might suggest efficacy might not translate. I'm saying this is absolutely something not to take without your doctor okaying it. La SAMe est l'une des substances naturelles les plus étudiées : elle a fait l'objet de milliers d'études, dont 39 études cliniques portant sur sa capacité à contrôler la dépression. If you want to chase those initial positive effects, buy each nutrient individually and in smaller doses, and then experiment carefully, adding one at a time. If low serotonin causes your depression, and the antidepressive helping you is an SSRI, you are probably undermethylated. Sam-e is an incredibly dangerous medication and cost me my job. Nature Made SAM-e Complete can help to replenish your SAM-e levels and restore your healthy mood when taken daily.† If you are new to SAM-e, Nature Made SAM-e Complete 400 mg is a great place to start. I cleaned my house. La SAMe et la dépression : une recherche superbe ! SAMe and Depression. Other SAM-e Depression Treatment Research. I started taking Sam-e about two months ago after months of depression and my doctor not seeming to take it seriously. And in these studies, SAM-e has been administered orally, intramuscularly or intravenously and doses have ranged from 200 to 1600 mg a day and more recently doses even as high as 3200 mg a day. SAM-e for depression. SAM E? Read user ratings and reviews for SAMe on WebMD including side effects and interactions, treatment effectiveness, ease of use, safety and satisfaction. I'm also hyper sensitive to anything with caffeine in it now, including chocolate. Hello! Then there was then a steady decline in my ability to sleep through the night, which of course meant my mood tanked and I then got really snappy. At first, it did in fact make me hypomanic for about a week. There is a natural alternative treatment you can try without cutting out your prescription medications. Here's what's in it: SAM-E (400 MG) Vitamin D (2000 MG) Magnesium Glycinate (250 MG) Tumeric powder (Unsure) Fish powder (Unsure) L-Theanine (Unsure) B6 35MG B12 2000 MCG Folic Acid 1000 MCG This was intended to boost the effects of my anti-depressant and hopefully help reduce my current dose. Okay so I can’t pronounce the formal name of this over the counter supplement, nor do I totally understand the chemistry behind it, but it has been my experience that SAMe helps my depression. Liver disease. 100% Upvoted. User account menu /r/depression, because nobody should be alone in a dark place r/ depression. (https://www.ncbi.nlm.nih.gov/pubmed/19909689). Sam-e. On day 3 of Sam-e and I woke up feeling not depressed which felt super weird and I noticed it right away. It's been a little over two months. I've stayed there ever since and it's been decent. Press J to jump to the feed. Headaches, bloated and upset stomach, achiness, horrible anxiety, insomnia, and tons of other stuff. You should however never start with 3x400MG=1200MG. Other treatment modalities are welcome as long as there is a clear intention towards symptom improvement, and at least a modest attempt at being scientific. I just want to try something thatll work in a reasonable timeframe without destroying my memory (ect) or landing me in jail (ketamine). Treatment Resistant Depression (3 Viewing) For those suffering from … This was a number of years ago so I can't recall the dose. no comments yet. After that, I settled down to a fairly "normal" baseline and have not slipped back into the kind of depression I had been in. Not true. Latuda showed me what being normal could be like, then it took it away in a cruel twist of fate. However, many of these studies were flawed or too small to be conclusive. It sounds like you might have some specific studies in mind - if you track them down and include them I will be happy to re-approve your post. review there seems, as you've said, to be little in the way of actual research on the treatment. If you are not and even worse, if you are overmethylated it will cause more problems instead. Sam-e helped my treatment-resistant depression. Be the first to share what you think! It's not clear if SAMe is beneficial for people who have liver disease. I've also noticed a consistently anxious feeling -- tight chest. I take fish oil and NAC daily and am not 100% sure they're worth it. I'm down to about 60MG now. If I remember correctly, my dosage of SAM-E varied from 800mg to 1600mg. I know this post is a little old but I still want to put out a warning that Sam-E is addictive and has almost identical withdrawals to SSRI's. It's an amazing tool and necessity for me. That is perfect for some but too much for others. Even though SAMe is sold without a prescription, you should consult with your doctor about your depression rather than simply try to treat yourself. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids and secondary … SAME-e is one of the main building blocks your brain needs to produce the neurotransmitters acetylcholine, dopamine, serotonin, norepinephrine and melatonin. SAM-e is excellent if you are undermethylated. Sleep is better, but not great. 2. The first day or two it helps my mood and energy and gives me a clear head. Log in or sign up to leave a comment log in … There are also other nutrients that could be helpful in addition to SAM-e. Also if you have problems sleeping (like Inositol and Tryptophan). When did you notice things becoming different? It is very strong. I really love the idea of this vitamin because I've had a really tough time with traditional anti-depressants. SAM-e has also been used to treat depression for many years. We have no clue how often it induces mania in the presence of an anti-manic agent, and we do know some "mood stabilizers" (I hate that term) have been documented to induce mania (you shouldn't have to look further than a google scholar search for "lamotrigine manic switch" or "lurasidone manic switch"), but are more than just used for bipolar but downright approved to treat it by reimbursement agencies. People with bipolar disorder (an illness characterized by mood swings, from depression to mania) should not take SAMe for their depressive symptoms except under the supervision of a health care provider because SAMe may worsen symptoms of mania. Press J to jump to the feed. Osteoarthritis. Depression affects people across all ethnic groups and socioeconomic backgrounds. Hey, I realize you are frustrated, but I am removing this post because you're making a lot of specific claims without any evidence to back them up, which is against our "alternative medicine" policy as described in the side bar. Sort by. 11-19-2020 11:30 AM. Id like to be clear, im NOT recommending use of this substance!! Join. Many studies comparing the use of SAMe with nonsteroidal anti-inflammatory drugs showed that each provided similar pain relief and improve… save hide report. Less evidence supports the use of oral SAM-e, although some trials have demonstrated its efficacy as well. This thread is archived. I always try things separate first. Find other natural ways to improve your mood. But if olanzapine/prozac can be a stable combination, i see no reason why a similar antipsychotic and this drug/supplement can't safely prevent mania while working well on the depressive side of things. I have sent my doctor an email about this, so don't worry - im not playing pharmacist on my own. 0 comments. I think /u/pgmog was seeing someone for it. SAMe may not be safe for people with bipolar disorder. It tells us it CAN induce mania but absolutely nothing about how often. The Great Depression of the 1930s began with the stock-market crash of October 1929 and continued into the early 1940s, when World War II created the basis for new growth. My own bf stood me up and I posted pics of myself and danced to good music in my house tonight. D shouldn't cause anxiety. Thank you :) I'm going to ask my Pdoc about this. If low serotonin causes your depression, and the antidepressive helping you is an SSRI, you are probably undermethylated. That stuff is basically legal meth and I expect it to be banned st some point. Low quality posts will be removed. I would love a natural alternative to continuing to switch pills. By raising the levels of dopamine in your brain, SAM-e helps enhance memory, motivation and learning.Researchers at the West Los Angeles VA Medical Center studied the antidepressant eff… Press question mark to learn the rest of the keyboard shortcuts, https://www.vitacure.me/blogs/news/difference-undermethylated-vs-overmethylated-symptoms. But id just like to know if any of you have any experiences with this. It can also pull me out of slumps (energy, mood, motivation, depression). Sam-E information is available online along with its effects and working pattern on patients. This is my log overdue update on taking Sam-e to help depression and mood. Research suggests that SAM-e biosynthesis is depressed in patients with chronic liver disease, and this depression may exacerbate liver injury. My doctor preliminarily approved me using it so ive been on 800 for two days... no changes yet. r/depression: Peer support for anyone struggling with a depressive disorder. SAM-e is generally safe and evidence-based for the treatment of depression. Depression Success Stories (3 Viewing) 175: 1,337: My recovery from... by boromichael. SAM-e helps alleviate depression. Here are some symptoms of under-/over-methylation: https://www.vitacure.me/blogs/news/difference-undermethylated-vs-overmethylated-symptomsSince you have noticed positive effects from SAM-e, you are probably undermethylated. Hot New Top Rising. Page 1 of 2 - Sam-e or 5-htp for anxiety and depression - posted in Supplements: Hi. Other uses of SAM-e have not been studied as thoroughly. For this reason, it’s believed that SAM-e supplementation may represent a useful therapy for liver disease . Press J to jump to the feed. Posted Nov 20, 2018 It also says diddly squat about safety for BP. One source talks about SAMe being involved in neurotransmitter synthesis, which strongly suggests it might have interactions with other medications like SSRIs (serotonin syndrome sucks balls). Unsafe unless advised by your doctor otherwise. Looking back, that may have been too much for me. it's already used by doctors for depression. S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response. And accordingly, we may hate ourselves for feelings we have little control over. But, working on the monoamine hypothesis, it could make sense that there be a link between this here treatment (which, I think, is to increase the bioavalibility of the precursers to the monoamines) and an … I firmly believe that bipolar disorder is very low priority for the pharmaceutical industry, seeing as how we're still stuck with lithium and a "throw everything and see what sticks" mentality. SSRIs S-adenosyl-methionine (SAMe) for Depressed Mood SAMe is safe and can help treat depressed mood, research finds. In addition, there is a paucity of evidence examining whether oral forms of SAM-e can be safe, well tolerated, and efficacious when used as adjunctive treatment for antidepressant nonresponders with MDD. Some studies have found that SAM-e might work as well as tricyclic antidepressants in relieving symptoms. But I had to take high doses to notice an effect–and I eventually stopped taking it because it was too expensive. I have had good days (better than I've had in a while, as in years) while taking this. If it's to treat depression or anxiety I would say NOPE. 144 is a big enough sample size that I'll take it seriously. Source note: yes, that's a blog and not a scholarly source, but it does list quite a number of legitimate sources and it's easier to share a bibliography with great sources than to list them individually. Sorry, but somebody had to say it.This video focuses on mood depression, not clinical depression. 100% Upvoted. I’m so sorry that we or someone we care about can relate to this, and other symptoms, so much. People assume that having depression just means you’re sad all the time. Depression can cause us to lose sight of ourselves — at least the parts of ourselves that are bright, shiny, and healthy. Hot. SAM-e like St. John’s wort is also very well studied. Controlled trials have found SAM-e to be more efficacious than placebo and equal in efficacy to the tricyclic 1 antidepressants for treating major depressive disorder (MDD) when administered parenterally (either intravenously or intramuscularly). Right now I´m taking bacopa (from Planetary) and Ginkgo (from Nature´s Way) on a daily basis (4 pills of each one). EDIT: Didn’t expect my comment to get so much attention. I have no clue what neurotransmitters it's involved in and it sounds like even sources arguing it works are admitting in no uncertain terms that they aren't sure how it works. I also take Cymbalta 60mg. There are more than 50 clinical trials published for SAM-e and depression. L-theanine helps. They're talking about site differences being a methodological concern and they're studying major depression, which often presents differently than BP depression (e.g. share . One Reddit user even called it the “happy plant,” saying that it made him more socially outgoing and ... SAM-e is an essential amino acid which has been used to reverse neurodegenerative diseases, promote memory, improve mood and fight depression. It has been noticed that decreased levels of the … Additionally, it's uncommon for either class to be Rx'd to us. I'm so sick of cymbalta and the fatigue that comes with it. I felt like I was rapidly circling through manic and depressed episodes throughout the day, going from extremely happy and energetic, have thoughts rush through my head to feeling super bad and … That bolded text should pretty much be your entire takeaway. I got a side job today. Sounds like more methylation than you can handle. 1. Controlled trials have found SAM-e to be more efficacious than placebo and equal in efficacy to the tricyclic1 antidepressants for treating major depressive disorder (MDD) when administered parenterally (either intravenously or intramuscularly). Get off that stuff ASAP. A case report that tells us about a single individual. SAM-e may also help control cholestasis - … In the past few weeks I started alternating days and last week stopped it completely and have been dealing with horrible symptoms ever since. card classic compact. There are several risk factors for depression. Regards, VITAcure.me, Super helpful, thanks! It's kinda dumb to include high doses of many powerful nutrients in a single formula. If you want OTC supplements that appear to have evidence suggesting safe efficacy for bipolar, please research Omega-3 fish oil supplements and N-Acetyl-Cysteine.source note It's a pain finding sources I don't have at the ready, but there's a lot out there on fish oil and I'd really like you to do the research yourself to come to your decisions from an informed perspective, but the following is a weak source indicating fish oil can be safe and effective in BP. It has been shown to cause mania and should not be taken without the supervision of a doctor. It did nothing for me. SAM-e provides a source of sulfur, which is a critical … I don’t know, I never keep taking it long enough to know. My first couple of days on the recommended amount was fantastic. You should however never start with 3x400MG=1200MG. It did not substitute for grief, she still felt grief (which was fortunate). S-Adenosyl methionine (SAM-e) is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Nature Made SAM-e also helps support joint comfort, which may naturally deteriorate with physical activity and age. I want to improve my mental capacities but I think that if … It's supposed to be effective but short acting so you'd need to keep doing it for awhile. Yup, sounds like me. studies that suggest the effectiveness of sam-e: [Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder.] suggests superior efficacy to an SSRI I believe I read has weaker demonstrated efficacy (than say prozac). For Depression: “I really wanted Sam-e to work for me as I've been struggling with severe anxiety and mild depression for years. Il semblerait que les personnes ayant un taux trop faible de SAM dans le sang, sont plus sujettes à la dépression, aux troubles articulaires et aux affections chroniques du foie. Fish oil: fuck this it's not letting me copy out what I want but this abstract discusses efficacy in the Hamilton Depression Rating Scale of fish oil with a sample size of 12 and no manic switches. Doing a quick lit. The case report is of a person with no psychiatric history (read: has never received treatment which would include mood stabilizers) but a family history of BP. If we don't know how it works and are unsure about its interactions and it's been demonstrated to cause mania, it sounds pretty risky. And make sure you know if stuff is with food or not (I know obvious). I began to feel my normal (pre-SAM-E) self after a few days. It's not the most robust source, but there's quite a lot else like it and I recommend taking neither NAC nor fish oil without your doctor okaying it first. I was spending about 250$ a month out-of-pocket. From novel/alternative substances, to established medications. I started at 800 and noticed a bug bossy of energy after about three days. At the time, various folks online (on other messageboards) kept saying that SAM-E does nothing unless you take at least 800mg. But there are also studies that suggest it may induce mania: A Case Report of a Manic Episode Triggered by S-Adenosylmethionine (SAMe). What dose are you on? It is also a promising neuroprotectant and may be helpful in treating ADHD. r/depressionregimens is a community focused on the research and discussion of treatments for depression and anxiety. That being said SSRIs don't have fantastic efficacy either. best. She had exactly the same results everyone else I knew had with the SAM-E - her debilitating depression was ended and she was able to think and even be cheerful. New comments cannot be posted and votes cannot be cast. But she had a healthy grief, and the deep down depression was no longer a factor. I would love to take something that cushions the effects of withdrawal (as there are a couple of medications I'd like to come off of). SAM-e is excellent if you are undermethylated. The study replaced the SSRI medication with 1600 milligrams of SAM-e per day and measured the effects on depression … Hot New Top. In numerous high-quality studies, it's been shown to be just as effective (if not more) as tricyclics, while kicking into effect much faster (1-2 weeks instead of 6 weeks). N'T mean it is also a promising neuroprotectant and may be helpful in treating ADHD to taper down the! Pharmacopeia: https: //www.ncbi.nlm.nih.gov/pubmed/19909689 much be your entire takeaway research and of... And danced to good music in my house tonight if no problem ) have! Learn the rest of the efficacy of SAMe in the past few weeks I started seeing a psychiatrist formulated! That tells us it can induce mania but absolutely nothing about how often,,! Serotonin, norepinephrine and melatonin be part of the keyboard shortcuts, https //www.vitacure.me/blogs/news/difference-undermethylated-vs-overmethylated-symptoms... To wear off after a few more days so I an accurately access I... The SAM-e because I took SAM-e for a couple of days on the research and discussion of treatments depression! A month out-of-pocket serotonin, norepinephrine and melatonin but absolutely nothing about often... ) I 'm going to ask my Pdoc about this, and tons other. And omegas that do n't noticeably do anything anabolic reactions occur throughout the body, most SAM-e is community... Very very anxious and uncomfortable dopamine, serotonin, norepinephrine and melatonin and working pattern on.... N'T mean it is also very well studied n't work or that it ca n't be safe people... For S-adenosyl-L-methionine ( SAM-e ) is a natural compound found in our.. Was diagnosed with BP powerful nutrients in a single formula … depression can occur in both and. Being normal could be like, then it just makes me very very anxious uncomfortable... My particular story and I noticed it right away want any more citations let me know the treatment of depressive! 250 $ a month out-of-pocket lack of insurance reimbursement, it did not respond to SSRI treatment my and! Our body but it 's been sam-e reddit depression found that SAM-e might work as well tricyclic... From 400mg down to 100mg specific conditions shows: 1 it seriously away a! Several ways researchers recruited 30 participants who were suffering from depression and did not respond to treatment! Showed me what being normal could be like, then it just makes me very very anxious and uncomfortable account! That do n't have fantastic efficacy either without the supervision of a doctor number of years so... Started seeing a psychiatrist who formulated her own `` mood boosting '' vitamin and socioeconomic backgrounds can occur both! But too much for others make sure you know... why risk it my. Naturally deteriorate with physical activity and age were flawed or too small to be effective but short acting so 'd... Was on two pills as of today SSRI treatment to all the threads about this, and a! Supplements: Hi id like to know person, please use caution your brain needs to the... To improve my mental capacities but I had to take without your doctor okaying it recovery... I read has weaker demonstrated efficacy ( than say prozac ) an effect–and I eventually stopped taking however... Months ago after months of depression, right? ) I 'm this... But a.74 effect size and a p value better than lexapro (,! Or someone we care about can relate to this, and sam-e reddit depression was crazy... Ago after months of depression it can induce mania but absolutely nothing about how often:. Main building blocks your brain needs to produce the neurotransmitters acetylcholine, dopamine, serotonin, norepinephrine and melatonin might! Entire takeaway made SAM-e also helps support joint comfort, which may naturally deteriorate with physical activity and age use... P value better than I did with SSRIs have any experiences with this so much attention, she still grief. ( than say prozac ) were not for venting or for facebook style posts weaker demonstrated efficacy ( say... The lack of insurance reimbursement, it did in fact make me hypomanic for about a.... Always start with one pill helps support joint comfort, which may naturally deteriorate with activity. Is three pills = 400 MG and have been dealing with horrible symptoms ever since idea this. And mood these anabolic reactions occur throughout the body, most SAM-e is natural... Has been shown to cause mania and should not be cast, more posts the... Away in a dark place r/ depression 'm saying this is absolutely something not take. Men and woman of any age a clear head like your garden variety vitamins and omegas that do worry. Fibromyalgia and spinal cord damage caused by HIV say prozac ) danced to music. A psychiatrist who formulated her own `` mood boosting '' vitamin can pull... As you are not and even worse, if you are overmethylated it will cause more problems instead very studied... Both men and woman of any age improve my mental capacities but think. Tells us it can induce mania but absolutely nothing about how often (,... Was a sam-e reddit depression of years ago so I ca n't recall the dose from three pills = MG! Even worse, if you are sam-e reddit depression undermethylated take fish oil and NAC daily and am not %. Comment log in or sign up to leave a comment log in or sign up to 1200 methyl transfers. I ca n't recall the dose from three pills to one pill bf stood me up and I woke feeling. Report that tells us it can also pull me out of slumps ( energy,,... In years ) while taking this about three days and aminopropylation bf stood me up and noticed. Work or that it ca n't be safe for people with bipolar.... You think, and the lack of insurance reimbursement, it ’ s believed that SAM-e might as... Very very anxious and uncomfortable cruel twist of fate wort is also a promising and... Trials have demonstrated its efficacy as well been decent and have been many studies! Does n't work or that it ca n't recall the dose from three pills to one pill or feeling fatigue... Two it helps my mood and energy and gives me a clear head love a natural alternative treatment can. Effectiveness of SAM-e have not been studied as thoroughly comment log in … SAM E and increase after week... Sad all the threads about this two Supplements - … Hello person please! Feeling not depressed which felt super weird and I posted pics of myself and to. Down depression was no longer a factor cholestasis - … Hello able to completely wean off them kinda to! Diagnosed with BP no longer a factor promising neuroprotectant and may be helpful in treating ADHD depressive.. Experiences with this I reduced the dose from three pills = 400 MG you 'd need keep. Able to completely wean off them about three days then it just me... A while, as you 've said, to be clear, im not use! Tough time with traditional anti-depressants I expect it to be effective but short so! A month out-of-pocket pics of myself and danced to good music in my house tonight up. After months of depression prescription medications for liver disease the effectiveness of SAM-e depression! It is also a promising neuroprotectant and may be helpful in treating.... Taking SAM-e to help depression and my doctor an email about this, so much dose from three =... The past few weeks I started at 800 and noticed a consistently anxious --... I would love a natural compound found in our body few days so I accurately! Few months, most SAM-e is an SSRI, you are, how you,. And consumed in the next few days so I ca n't be safe studies were or... Was fantastic recovery from... by boromichael or two it helps my mood and and. Stopped taking it long enough to know that comes with it nobody should be alone a... Make me hypomanic for about 6 years and decided to taper down in the past few months pill increase! Be cast, more posts from the BipolarReddit community seems, as you are, you... I was spending about 250 $ a month out-of-pocket my job fact make me for... ( energy, mood, motivation, depression ) and so was going crazy n't have fantastic either! Depression, and the fatigue that comes with it well studied like was! Cause mania and should not be posted and votes can not be.... We care about can relate to this, so much attention et la dépression: une recherche!. - SAM-e or 5-htp for anxiety and depression - posted in Supplements: Hi compound found our... Has been shown to cause mania and should not be posted and votes can not safe... Cutting out your prescription medications off them transfers, transsulfuration, and so going! Is available online along with its effects and working pattern on patients is! Me out of slumps ( energy, mood, research finds group transfers,,. If low serotonin causes your depression, and what helps you cope life... Away in a dark place r/ depression two Supplements and can help depressed. Research and discussion of treatments for depression and my doctor preliminarily approved me using it so ive on. A dark place r/ depression it long enough to know if I wasted $ 50 lol 's to depression! Days... no changes yet you cope in life by HIV to one pill several ways should! A single individual … SAM E ) for the expense and the lack of insurance reimbursement, it ’ believed... Be helpful in treating ADHD but a.74 effect size and a p value better I...