Whenever two or more drugs are being taken, there is a chance that there will be an interaction among the drugs. Moderate Potential Hazard, Moderate plausibility. There are 3 disease interactions with Epclusa (sofosbuvir / velpatasvir) which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Prior to the completion of this project, many of the interactions with the HBV drugs … Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Drug interactions contribute to the cost of healthcare because of the costs of medical care that are required to treat probl… Drugs & Medications Epclusa Relugolix/P-glycoprotein (P-gp) Inhibitors Interactions This information is generalized and not intended as specific medical advice. Avoid these practices. Sofosbuvir - velpatasvir is used alone or with ribavirin to treat chronic (long-term) hepatitis C virus (HCV) infection. dose of one or both drugs: combo may incr. Most drug interactions are not serious, but because a few are, it is important to understand the possible outcome before you take your medications. Drugs affecting sofosbuvir/velpatasvir. Epclusa is contraindicated with phenobarbital and phenytoin (see section 4.3). Although we attempt to provide accurate and up-to-date information, no … Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. All patients should be tested for evidence of current or prior HBV infection by measuring HBsAg and anti-HBc before starting HCV direct-acting antiviral therapy. HBV reactivation has been reported during or after completion of HCV direct-acting antiviral therapy in HCV/HBV-coinfected patients who were not receiving HBV antiviral therapy; some cases resulted in fulminant hepatitis, hepatic failure, and death. Avoid combinations; the risk of the interaction outweighs the benefit. Carbamazepine (Induction of P-gp and CYPs) Interaction not studied. For example, famotidine, and proton pump inhibitors (PPIs) because they may decrease the effectiveness of Epclusa treatment … Moderately clinically significant. Epclusa (sofosbuvir and velpatasvir) is used to treat hepatitis C. Includes: uses, side effects, interactions and indications. Interactions with hepatitis B drugs Over the past few months, we have been working on a project to include full interactions with the hepatitis B drugs which has involved assessing and adding ~6700 new interactions. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Consumer; Professional; FAQ; Note: This document contains side effect information about sofosbuvir / velpatasvir. A total of 111 drugs are known to interact with Potential for Other Drugs to Affect EPCLUSA 7.2 Potential for EPCLUSA to Affect Other Drugs : 7.3 Established and Potentiall y Significant Drug Interactions : 7.4 Drugs without Clinically Significant Interactions … Some of the dosage forms listed on this page may not apply to the brand name Epclusa… This tool may not cover all possible drug interactions. Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP while GS-331007 (the predominant circulating … Drug Interaction Checker. The likelihood of drug interactions increases as the number of drugs being taken increases. Sofosbuvir is extensively metabolized in the liver. sofosbuvir, Vosevi, Sovaldi, Mavyret, Harvoni, ribavirin. Cases have been reported in hepatitis B surface antigen (HBsAg)-positive patients and patients with serologic evidence of resolved HBV infection (i.e., HBsAg negative and hepatitis B core antibody [anti-HBc] positive). Ideally, you should try to upgrade your browser to the latest version in order to use our full featured interaction checker. Epclusa Side Effects. The safety and efficacy of sofosbuvir as a single agent have not been established in patients with decompensated cirrhosis. Epclusa is contraindicated with … Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Some mixtures of medications can lead to serious and even fatal consequences. It is intended to be used as follows: If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. We would like to show you a description here but the site won’t allow us. Epclusa sofosbuvir 400 mg / velpatasvir 100 mg (GSI 7916). Are you sure you want to clear the Interaction Checker… HBV reactivation has also been reported in patients using certain immunosuppressant or chemotherapeutic agents; risk of HBV reactivation associated with HCV direct-acting antiviral therapy may be increased in these patients. Epclusa (sofosbuvir / velpatasvir). The interaction may increase or decrease the effectiveness of the drugs or the side effects of the drugs. Applies to: Immunodeficiency, Infectious Hepatitis. A series of mini-lectures on topics including pharmacology, hepatitis and drug-drug interactions Prescribing Resources. Interaction Checker. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Select one or more newsletters to continue. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Minimally clinically significant. View interaction reports for Epclusa (sofosbuvir / velpatasvir) and the medicines listed below. Drug interactions of Epclusa include acid reducing agents that are commonly used to treat heartburn, indigestion, and GERD, such as antacids, histamine 2 receptor antagonists. Therefore, people who take several drugs are at the greatest risk for interactions. morphine levels, risk of CNS and resp. Avoid combinations; the risk of the interaction outweighs the benefit. Drug interaction overview. No dosage recommendation can be given for patients with severe renal impairment or ESRD. Drugs & Medications Epclusa BCRP, OATP1B1, and OATP1B3 Substrates/Enasidenib Interactions This information is generalized and not intended as specific medical advice. Show all medications in the database that may interact with Epclusa (sofosbuvir / velpatasvir). Moderate Potential Hazard, Moderate plausibility. GT 1, 2, 4, or 6 patients were randomized 5:1 to receive EPCLUSA … Applies to: Liver Disease, Cirrhosis. Access our free, comprehensive and user-friendly drug interaction charts Educational Videos. ASTRAL-1: Double-blind, placebo-controlled trial in GT 1, 2, 4, 5, or 6 patients (N=740). Usually avoid combinations; use it only under special circumstances. Expected: ↓ Velpatasvir. However, if that is not possible or if local settings are preventing the checker … Type in a drug name to check for interactions with Epclusa (sofosbuvir / velpatasvir). Minimally clinically significant. Interaction … Epclusa : - Store and dispense in original container - Store below 86 degrees F. ... drug-induced hepatic injury, complex drug interactions, overlapping toxicities); therefore, it is recommended to initiate a fully … No dosage adjustment is necessary for patients with mild or moderate renal impairment. Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. Epclusa sofosbuvir 400 mg / velpatasvir 100 mg (GSI 7916). Learn more about Epclusa … Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. The following chart provides information regarding potentially significant drug interactions with Epclusa (the table is not all-inclusive). EPCLUSA can cause serious side effects, including: • Hepatitis B virus reactivation: Before starting EPCLUSA treatment, your healthcare provider will do blood tests to check for hepatitis B infection. We comply with the HONcode standard for trustworthy health information -. Etoricoxib Interaction with 583 drugs. ASTRAL-1: Double-blind, placebo-controlled trial in GT 1, 2, 4, 5, or 6 patients (N=740). Highly clinically significant. It is possible that side effects, such as a reduced number of red blood cells, may develop if these drugs … Sofosbuvir/Velpatasvir = Epclusa® Ledipasvir/Sofosbuvir = Harvoni® • Acid-reducing medications can decrease the effectiveness of Harvoni® and Epclusa… Select one or more newsletters to continue. GT 1, 2, 4, or 6 patients were randomized 5:1 to receive EPCLUSA … depression, psychomotor impairment, other adverse effects (P-gp-mediated transport … The safety and efficacy of sofosbuvir as a single agent have not been established in patients with severe renal impairment (eGFR less than 30 mL/min/1.73m2) or ESRD requiring hemodialysis. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Taking a medication that was prescribed for someone else or bought off of the Internet can be dangerous, too and lead to unexpected drug interactions. Available for Android and iOS devices. sofosbuvir, Vosevi, Sovaldi, Mavyret, Harvoni, ribavirin. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Generic Name: sofosbuvir / velpatasvir Medically reviewed by Drugs.com. This material is provided for educational purposes only … Available for Android and iOS devices. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. Use the search field above to look up prescription or OTC drugs, and herbal supplements; Add a full drug regimen and view interactions . Summary: 9 females aged 63 (±5) who take the same drugs … We comply with the HONcode standard for trustworthy health information -. Both of these medications belong to the class of medications called antivirals. rate, consider decr. Use of EPCLUSA with Inducers of P-gp and/or Moderate to Strong Inducers of CYP 5.4 Risks Associated with Ribavirin and EPCLUSA Combination Treatment 6 ADVERSE REACTIONS 6.1 Clinical Trials Experience 6.2 Postmarketing Experience 7 DRUG INTERACTIONS 7.1 Potential for Other Drugs to Affect EPCLUSA 7.2 Potential for EPCLUSA to Affect Other Drugs Interactions with Harvoni ® and Epclusa ® November 2016 | www.hepatitis.va.gov. EPCLUSA is a combination of two anti-viral drugs: sofosbuvir (previously approved for HCV treatment) and velpatasvir (new drug for HCV). Applies to: Renal Dysfunction. Patients with serologic evidence of current or prior HBV infection should be monitored for clinical and laboratory signs of hepatitis flare or HBV reactivation during HCV therapy and posttherapy follow-up; appropriate patient management for HBV infection should be started as clinically indicated. There are 111 drug interactions with Epclusa (sofosbuvir / velpatasvir). Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID), prescribed for osteoarthritis, rheumatoid arthritis and gouty arthritis. Patients who were active injection drug users (use within 12 months), or those with a positive urine drug test at screening, were excluded from the ASTRAL pivotal trials. This combination product contains 2 medications: sofosbuvir and velpatasvir. Usually avoid combinations; use it only under special circumstances. Use WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. monitor resp. Notes for Consumers: Although an interaction is possible, these drugs can be used together with caution. Drug Interactions Checker; A study for a 63 year old woman who takes Claritin, Epclusa, Ambien, Anoro Ellipta, Humalog Mix 75/25, Neurontin, Bentyl, Dexilant, Metformin, Ibu, Lisinopril - from FDA reports. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Anytime you take more than one medication, or even mix it with certain foods, beverages, or over-the-counter medicines, you are at risk of a drug interaction. If you have ever had hepatitis B, the hepatitis B virus could become active again during and after treatment with EPCLUSA. 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